The crash happened on I-81 North at mile marker 52 shortly after 3 p.m., PennDOT's Fritzi Schreffler told Daily Voice.
The lane restriction is between Exit 52B: US 11/TO I-76 Turnpike - Middlesex and Exit 57: PA 114 - Mechanicsburg.
There was no word on any injuries as of 4 p.m. as emergency crews remained on the scene.
There is also rubbernecking reported on I-81 southbound at Exit 52: US 11/TO I-76 Turnpike - Middlesex.
Schreffler is unsure when the roadway will reopen.
Check back here for possible updates.
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